Adoptive Transfer of Delayed Wattle Reactivity in Chickens with a Dialyzable Leukocyte Extract Containing Transfer Factor
نویسندگان
چکیده
منابع مشابه
Immunotherapy with Dialyzable Leukocyte Extracts Containing Transfer Factor
Dialyzable leukocyte extracts (DLE) are complexes consisting of a large number of low molecular weight substances. These extracts possess immunomodulatory properties, which are mainly attributed to small peptides with molecular weight of 3.5–6.0 kDa called “transfer factor.” This chapter reviews the nature and immunological characteristics of DLE containing transfer factor (TF), their mechanism...
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Dialyzable Leukocyte Extract (DLE) is an extract obtained from immune lymphocytes capable of transferring antigenspecific information for cell-mediated immunity (CMI) from an immunized donor to a naïve recipient. Those products, also called Transfer Factors (TF), are peptides of 3500-6000 kDa in molecular weight; light yellow fluid with pH 6.5-7.0, composed of oligoribonucleotides attached a pe...
متن کاملTransfer of delayed hypersensitivity in mice to microbial antigens with dialyzable transfer factor.
Dialyzable Lawrence-type transfer factor was prepared from the spleen cells of CF1 mice inoculated with Coccidioides immitis- and Candida albicans-killed vaccines and with live Mycobacterium tuberculosis vaccine (BCG). These preparations were shown to transfer antigen-specific cell-mediated immunity to naive mice, as measured by the delayed skin test and footpad-swelling methods. Reactivity cou...
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Five patients with advanced breast cancer were treated with pooled dialyzable transfer factor from healthy adult donors. The period of treatment ranged from 21 to 310 days, the total dose from 20 to 257 ml. Transfer factor did not elicit inflammatory or hypersensitivity reactions or detectable formation of antibody to itself, nor any hematological or biochemical abnormalities or other side effe...
متن کاملIn vitro properties of leukocyte dialysates containing transfer factor.
The chief impediment to the precise biochemical identification of transfer factor and its mechanism of action has been the lack of a reproducible in vitro assay. We now report on a method by which dialysates containing transfer factor of proven in vivo potency can convert nonimmune lymphocytes to immune responsiveness in vitro, as reflected by antigen-triggered lymphocyte proliferation. However...
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ژورنال
عنوان ژورنال: Poultry Science
سال: 1983
ISSN: 0032-5791
DOI: 10.3382/ps.0620767